Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years
| Autor: | Christian Suren, Rüdiger von Eisenhart-Rothe, Jonathan Breitenbach, Heinrich M. L. Mühlhofer, Florian Pohlig, Ulrich Lenze, Carolin Knebel, Hans Rechl, Florian Lenze, Norbert Harrasser |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Survival Adolescent medicine.medical_treatment Liposarcoma Prognostic factors lcsh:RC254-282 03 medical and health sciences Young Adult 0302 clinical medicine Surgical oncology Biopsy Genetics medicine Humans Prospective cohort study Grading (tumors) Outcome Aged Neoplasm Staging Retrospective Studies Aged 80 and over Chemotherapy medicine.diagnostic_test business.industry Soft tissue Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Prognosis Survival Analysis Liposarcoma Myxoid ddc Surgery 030104 developmental biology Treatment Outcome Oncology 030220 oncology & carcinogenesis Resection margin Female Radiology Neoplasm Recurrence Local business Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017) |
| ISSN: | 1471-2407 |
| Popis: | Background Soft tissue sarcomas are rare entities with over 50 histological subtypes. Liposarcoma (LS) is the most common neoplasm in this group; it is a complex neoplasm that is divided into different histological subtypes. Different therapy options, such as surgical resection, radiation, and chemotherapy, are available. Depending on the subtype, location, status of the resection margins and metastatic status, different therapy options are used. Therefore, the aim of this study was to determine the prognostic factors influencing the survival of patients affected by LS with consideration for the grading, histological subtype, state of the resection margin, size, location, metastases and local recurrence in a retrospective, single-centre analysis over 15 years. Methods We included 133 patients (male/female = 67/66) in this study. We recorded the histologic subtype, grade, TNM classification, localization, biopsy technique, tumour margins, number of operations, complications, radiation and dose, chemotherapy, survival, recrudescence, metastases and follow-up. Survivorship analysis was performed. Results We detected 56 (43%; 95%-CI 34.6–51.6%) atypical LS cases, 21 (16.2%; 95%-CI 9.8–22.5) dedifferentiated LS cases, 40 (30.8%; 95%-CI 22.8–38.7) myxoid LS cases and 12 (9.2%; 95%-CI 4.3–14.2) pleomorphic LS cases. G1 was the most common grade, which was followed by G3. Negative margins (R0) were detected in 67 cases (53.6%; 95%-CI 44.9–62.3) after surgical resection. Local recurrence was detected in 23.6% of cases. The presence of metastases and dedifferentiated LS subtype as well as negative margins, grade and tumour size are significant prognostic factors of the survival rates (p |
| Databáze: | OpenAIRE |
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