Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats
| Autor: | Servet Kiliç, Tuba Özge Yaşar Erkal, Funda Terzi, Fatih Hatipoglu |
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| Přispěvatelé: | Selçuk Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Popis: | WOS: 000472915800023 Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 mu g/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 mu g/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels. Scientific Projects Research Commision of Namik Kemal University [NKUBAP.10, 16.019] This study was supported by the Scientific Projects Research Commision of Namik Kemal University (Project no: NKUBAP.10.GA.16.019). |
| Databáze: | OpenAIRE |
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