A Meta-analysis of Gut Microbiota in Children with Autism
| Autor: | Alejandro Veas, Pedro Andreo-Martínez, Agustín Ernesto Martínez-González, María Rubio-Aparicio, Julio Sánchez-Meca |
|---|---|
| Přispěvatelé: | Universidad de Alicante. Departamento de Psicología de la Salud, Universidad de Alicante. Departamento de Psicología Evolutiva y Didáctica, Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE), Habilidades, Competencias e Instrucción, Grupo de Investigación Integral en el Neurodesarrollo Típico y Atípico (GINTA) |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Autism Spectrum Disorder Gut microbiota Gut flora medicine.disease_cause digestive system 03 medical and health sciences Psicología Evolutiva y de la Educación 0302 clinical medicine Internal medicine mental disorders Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Autistic Disorder Child Bifidobacterium Bacteria biology Streptococcus 05 social sciences Microbiota-gut-brain axis medicine.disease biology.organism_classification Autism spectrum disorders (ASD) Child development Gastrointestinal Microbiome Meta-analysis Reporting bias Personalidad Evaluación y Tratamiento Psicológico Systematic review Dysbiosis Autism Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Zdroj: | JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname RUA. Repositorio Institucional de la Universidad de Alicante Universidad de Alicante (UA) |
| ISSN: | 1573-3432 0162-3257 |
| Popis: | Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD(+) = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD(+) = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias. |
| Databáze: | OpenAIRE |
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