Human immunodeficiency virus gp120 downregulates CD1d cell surface expression
| Autor: | Chadi A. Hage, Sungyoo Cho, Kenneth S. Knox, Lisa L. Kohli, Homer L. Twigg, Randy R. Brutkiewicz |
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| Rok vydání: | 2005 |
| Předmět: |
T-Lymphocytes
CD14 Immunology Down-Regulation chemical and pharmacologic phenomena HIV Envelope Protein gp120 Major histocompatibility complex Antigens CD1 Jurkat Cells Antigen MHC class I medicine Humans Immunology and Allergy Immunodeficiency biology business.industry Monocyte virus diseases hemic and immune systems U937 Cells medicine.disease Virology Lymphocyte Subsets Killer Cells Natural carbohydrates (lipids) medicine.anatomical_structure CD1D HIV-1 biology.protein Biological Assay lipids (amino acids peptides and proteins) Antigens CD1d business Viral load |
| Zdroj: | Immunology Letters. 98:131-135 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2004.10.025 |
| Popis: | CD1d is an MHC class I-like surface molecule that presents endogenous glycoplipid antigens. The effect of HIV infection on CD1d surface expression has not yet been reported. FACS analysis revealed significantly lower levels of CD1d on CD14 + monocytes from HIV-infected subjects compared to HIV-infected subjects on HAART and healthy controls. CD1d expression correlated inversely with viral load in infected individuals. CD1d surface expression on human cell lines was downregulated after infection with M-tropic HIV, T-tropic HIV, or after exposure to HIV gp120 in vitro. These data suggest that CD1d-mediated responses are altered during HIV infection and may thus contribute to the global immunodeficiency seen in these patients. |
| Databáze: | OpenAIRE |
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