Testosterone Plasma Concentration is Associated with Insulin Resistance in Male Hypertensive Patients
| Autor: | Mattia Bellan, Mario Pirisi, Antonello Gibbin, Fabio Brustia, Alice Pirovano, Michela Gentile, Alessandro Gualerzi, Gian Piero Carnevale Schianca, Gian Paolo Fra, Mirta Menegatti, Ettore Bartoli |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypothalamo-Hypophyseal System Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Diabetes mellitus Internal medicine Testis Internal Medicine medicine Humans Testosterone Prediabetes business.industry Type 2 Diabetes Mellitus Testosterone (patch) General Medicine Middle Aged medicine.disease Diabetes Mellitus Type 2 Hypertension Insulin Resistance Luteinizing hormone business 030217 neurology & neurosurgery Homeostasis Hormone |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 125(3) |
| ISSN: | 1439-3646 |
| Popis: | Background: Low testosterone levels are a common finding among men with Type 2 Diabetes Mellitus (T2DM) and are inversely related to insulin resistance. Whether this relationship holds true in patients with hypertension, but normal glucose tolerance or prediabetes, is unclear. Methods: We recruited 87 male outpatients with essential arterial hypertension, aged 35–70 years. Anthropometric data were collected, an Oral Glucose Tolerance Test (OGTT) performed, and the homeostasis model assessment of insulin resistance (HOMA-IR) score calculated. Follicle-Stimulating Hormone, Luteinizing Hormone, testosterone, Sex Hormone-Binding-Globulin and free-testosterone were measured. The concentrations of sex hormones were compared between normoglucotolerant, prediabetic and diabetic patients. Non-parametric tests were applied as appropriate to verify differences among groups, while multiple linear regression was used to predict the variability of testosterone and free-testosterone. Results: Total serum testosterone concentration was significantly lower in T2DM in comparison to normoglucotolerant subjects (p Conclusions: In males with hypertension, the link between insulin sensitivity and hypothalamic-pituitary-gonadal axis is maintained along the entire spectrum of glucose tolerance. |
| Databáze: | OpenAIRE |
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