EEG microstates associated with salience and frontoparietal networks in frontotemporal dementia, schizophrenia and Alzheimer’s disease
| Autor: | Yosuke Morishima, Kay Jann, Satoshi Irisawa, Toshihiko Kinoshita, Keiichiro Nishida, Werner Strik, Thomas Dierks, Thomas Koenig, Toshiaki Isotani, Masafumi Yoshimura |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adolescent Hallucinations Neuropsychological Tests Electroencephalography Brain mapping Young Adult Alzheimer Disease Parietal Lobe Physiology (medical) mental disorders medicine Humans Aged Tomography Emission-Computed Single-Photon Brain Mapping medicine.diagnostic_test Resting state fMRI Parietal lobe Middle Aged medicine.disease Magnetic Resonance Imaging Sensory Systems Frontal Lobe EEG microstates Neurology Frontal lobe Frontotemporal Dementia Schizophrenia Female Schizophrenic Psychology Neurology (clinical) Nerve Net Alzheimer's disease Psychology Neuroscience Frontotemporal dementia |
| Zdroj: | Clinical Neurophysiology. 124:1106-1114 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2013.01.005 |
| Popis: | OBJECTIVE: There are relevant links between resting-state fMRI networks, EEG microstate classes and psychopathological alterations in mental disorders associated with frontal lobe dysfunction. We hypothesized that a certain microstate class, labeled C and correlated with the salience network, was impaired early in frontotemporal dementia (FTD), and that microstate class D, correlated with the frontoparietal network, was impaired in schizophrenia. METHODS: We measured resting EEG microstate parameters in patients with mild FTD (n = 18), schizophrenia (n = 20), mild Alzheimer's disease (AD; n = 19) and age-matched controls (old n = 19, young n = 18) to investigate neuronal dynamics at the whole-brain level. RESULTS: The duration of class C was significantly shorter in FTD than in controls and AD, and the duration of class D was significantly shorter in schizophrenia than in controls, FTD and AD. Transition analysis showed a reversed sequence of activation of classes C and D in FTD and schizophrenia patients compared with that in controls, with controls preferring transitions from C to D, and patients preferring D to C. CONCLUSION: The duration and sequence of EEG microstates reflect specific aberrations of frontal lobe functions in FTD and schizophrenia. SIGNIFICANCE: This study highlights the importance of subsecond brain dynamics for understanding of psychiatric disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect