Association between time in range and cancer mortality among patients with type 2 diabetes: a prospective cohort study
| Autor: | Wei Lu, Yaxin Wang, Lei Zhang, Lei Chen, Yun Shen, Tian Xia, Jian Zhou, Wei Zhu, Gang Hu, Chunfang Wang, Jingyi Lu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
China medicine.medical_specialty HbA1c Range (biology) Cancer mortality Type 2 diabetes digestive system Neoplasms Internal medicine parasitic diseases Humans Medicine Prospective Studies Prospective cohort study business.industry Blood Glucose Self-Monitoring Original Articles General Medicine biochemical phenomena metabolism and nutrition medicine.disease Hepatocellular cancer Diabetes Mellitus Type 2 Time in range Cohort study business |
| Zdroj: | Chinese Medical Journal |
| ISSN: | 2542-5641 0366-6999 |
| Popis: | Background: Little was known about the association among time in range (TIR), time above range (TAR), time below range (TBR), and cancer mortality among patients with type 2 diabetes. We aimed to investigate the association among TIR, TAR, TBR, and the risk of cancer mortality among patients with type 2 diabetes. Methods: A total of 6225 patients with type 2 diabetes were prospectively recruited in Shanghai, China. TIR was measured with continuous glucose monitoring at baseline and was defined as the average percentage of time in the target glucose range during a 24 h period. Cox proportion hazard regression analysis was used to determine the association between TIR and the risk of cancer mortality. Results: During a mean follow-up of 7.10 years, we confirmed 237 death events related to cancer. The multivariable-adjusted hazard ratio (HR) for cancer mortality was 1.32 (95% confidence interval [CI]: 1.01–1.75) in patients with TIR ≤70% compared with those with TIR >70%. When TIR was considered as a continuous variable, the multivariable-adjusted HR for cancer mortality associated with each 10% decrease in TIR was 1.07 (95% CI: 1.02–1.14). In the site-specific analysis, a significant association between TIR as a continuous variable and the risk of hepatocellular cancer was found (HR: 1.24; 95% CI: 1.09–1.41). However, no relationship between hemoglobin A1c and cancer mortality was observed (HR: 1.04; 95% CI: 0.97–1.10). Conclusions: The present study found an inverse association of TIR with the risk of cancer mortality among patients with type 2 diabetes. New evidence of TIR was added into the clinical practice that TIR may be an optimal target of glycemic control among patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
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