Transgenic Sertoli Cells as a Vehicle for Gene Therapy
| Autor: | P. F. Gores, Dwaine F. Emerich, Jannette M. Dufour, Richelle Hemendinger, Craig Halberstadt |
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| Rok vydání: | 2004 |
| Předmět: |
Male
0301 basic medicine Cell Survival Genetic enhancement Transgene Cell Biomedical Engineering lcsh:Medicine Biology Animals Genetically Modified 03 medical and health sciences 0302 clinical medicine Immune privilege medicine Animals Humans Gene Immunosuppression Therapy Transplantation Sertoli Cells lcsh:R Genetic Therapy Cell Biology Sertoli cell Genetically modified organism Cell biology 030104 developmental biology medicine.anatomical_structure Immunology 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Cell Transplantation, Vol 13 (2004) |
| ISSN: | 1555-3892 0963-6897 |
| DOI: | 10.3727/000000004772664833 |
| Popis: | Gene therapy involves the manipulation of genetic material to replace defective or deficient proteins to restore function in disease states. These genes are introduced into cells by mechanical, chemical, and biological approaches. To date, cell-based gene therapy has been hampered by the lack of an abundant, safe, and immunologically acceptable source of tissue. As an alternative, transgenic animals designed to produce therapeutic proteins could overcome some of the issues facing gene therapy but the problem of immune rejection of the tissue remains. This article reports on recently published work indicating the potential to use transgenic Sertoli cells surviving in an allogeneic host by virtue of their ability to create a locally immunoprivileged environment, thereby providing for the continued delivery of a therapeutic protein to the systemic circulation. |
| Databáze: | OpenAIRE |
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