Hyperlipoproteinemia enhances susceptibility to acute disseminated candida albicans infection in low-density-lipoprotein-receptor-deficient mice
| Autor: | J.W.M. van der Meer, A.F.H. Stalenhoef, O.C. Boerman, P.N.M. Demacker, Mihai G. Netea, B.J. Kullberg, N. de Bont |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Diagnostic Imaging
Hyperlipoproteinemias medicine.medical_treatment Immunology Cholesterolmetabolisme en cytokinen Microbiology Sepsis Mice medicine Animals Humans Receptor Candida albicans Cholesterol metabolism and cytokines GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) biology Development of radiopharmaceuticals for diagnosis and therapy of pathological processes Candidiasis nutritional and metabolic diseases biology.organism_classification medicine.disease Corpus albicans In vitro Ontwikkeling van radiofarmaca ten behoeve van diagnose en behandeling van ziekteprocessen Mice Inbred C57BL Infectious Diseases Cytokine Receptors LDL LDL receptor Acute Disease The effect of interleukin-1 on resistance to infection Versterking van de weerstand tegen infecties door interleukine-1 Cytokines Parasitology lipids (amino acids peptides and proteins) Systemic candidiasis Disease Susceptibility Infection Research Article |
| Zdroj: | Infection and Immunity, 65, 2663-2667 Infection and Immunity, 65, 7, pp. 2663-2667 |
| ISSN: | 2663-2667 0019-9567 |
| Popis: | Recent studies have suggested the use of lipoproteins as an adjuvant treatment of lethal gram-negative infections. However, other important microorganisms for the etiology of sepsis, such as Candida species, grow better in lipid-rich environments. We investigated the effect of hyperlipoproteinemia on systemic candidiasis in low-density-lipoprotein-receptor-deficient (LDLR-/-) mice, in which the loss of the receptor results in a seven- to ninefold-higher plasma LDL level than that in their wild-type littermates (C57BL/6J). LDLR-/- mice died earlier, and the outgrowth of Candida albicans in the kidneys and livers of LDLR-/- mice was significantly higher compared with that of controls. After infection, circulating cytokine concentrations were significantly higher in LDLR-/- mice. In vitro, C. albicans grew better in plasma samples of LDLR-/- mice than in control plasma samples and peritoneal macrophages of LDLR-/- mice challenged with heat-killed C. albicans produced more cytokines than did those of controls. This latter phenomenon was probably due to increased binding of yeast cells to macrophages of LDLR-/- mice. These data suggest that hyperlipoproteinemia is deleterious in systemic candidiasis. |
| Databáze: | OpenAIRE |
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