Evaluation of Valuation of Toxicity Profile of an Alkaloidal Fraction of the Stem Bark ofPicralima nitida(Fam. Apocynaceae)

Autor:	S. O. Awe, Oludele A. Itiola, O. E. Ola-Davies, Titilayo O. Fakeye, H. A. Odelola, T. Obajuluwa
Rok vydání:	2004
Předmět:	Pharmacology Picralima Necrosis Apocynaceae biology Traditional medicine Dermatomycosis biology.organism_classification medicine.disease_cause Biochemistry Acute toxicity Toxicology medicine.anatomical_structure Toxicity medicine medicine.symptom Irritation Sensitization
Zdroj:	Journal of Herbal Pharmacotherapy. 4:37-45
ISSN:	1522-9106 1522-8940
DOI:	10.1080/j157v04n03_04
Popis:	Dermal and acute toxicity evaluation of the basic alkaloidal fraction of the stem bark of Picralima nitida, which has been shown to have pronounced activity against causative organisms of dermatomycosis in man, was carried out in animals. Acute intraperitoneal toxicity tests showed a dose-dependent toxicity. There was inflammation and necrosis of liver hepatocytes accompanied by reduction in neutrophilic count and a corresponding increase in lymphocytic count. There was no sign of reddening or irritation when applied into the eye conjunctiva. Dermal tests also showed that the fraction caused no sensitization, inflammation or death in the animal models used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dacc0be4bcecaeb530e2e7e6bf01aa https://doi.org/10.1080/j157v04n03_04 Zobrazit plný text záznamu