New insights into naevoid melanomas: a clinicopathological reassessment
| Autor: | Martin G. Cook, Vincenzo De Giorgi, Caroline Gaudy, Megan E. Grant, Senada Koljenović, Eleanor Kissin, Amaya Viros, Kiarash Khosrotehrani, A. Mandal, Gabriela Gremel, Richard Marais, Daniela Massi, Martin C. Mihm, Willeke A. M. Blokx, Nathalie Dhomen, Joost van den Oord, Adèle C. Green |
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| Přispěvatelé: | Pathology |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Histology Adolescent Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] Biology Pathology and Forensic Medicine Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Naevoid melanoma All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine medicine Humans Child Melanoma neoplasms Aged Aged 80 and over Nevus Pigmented Papilloma Manchester Cancer Research Centre Atypical cells ResearchInstitutes_Networks_Beacons/mcrc Cancer General Medicine Middle Aged Prognosis medicine.disease Dermatology Superficial spreading melanoma Small-cell melanoma 030220 oncology & carcinogenesis Female |
| Zdroj: | Histopathology, 71(6), 943-950. Wiley-Blackwell Publishing Ltd Histopathology, 71, 943-950 Histopathology, 71, 6, pp. 943-950 Cook, M, Massi, D, Blokx, W A M, van den Oord, J, Koljenovic, S, De Giorgi, V, Kissin, E, Grant, M, Mandal, A, Gremel, G, Gaudy, C, Viros Usandizaga, A, Dhomen, N, Khosrotehrani, K, Marais, R, Green, A & Mihm Jr, M C 2017, ' New insights into naevoid melanomas: a clinicopathological reassessment ', Histopathology . https://doi.org/10.1111/his.13317 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1111/his.13317 |
| Popis: | Aims Because the term ‘naevoid melanoma’ has variable clinical and pathologic interpretations, we aimed to clarify the features of melanomas referred to as naevoid. Methods and Results A review was undertaken of 102 melanomas diagnosed histopathologically as naevoid melanomas and ascertained by European Organisation for Research and Treatment of Cancer Melanoma Group Subcommittee pathologists from their records. We found these could be classified morphologically into 3 groups. Thirteen melanomas were overlying genuine naevi and were therefore excluded. Of the 89 melanomas considered to be naevoid, 11 presented clinically as exophytic papillomatous nodules with little junctional component and composed of small atypical cells showing numerous mitoses and no change with depth; we termed these “papillomatous naevoid” melanomas. The other 78 were flat or only slightly raised and had a superficial spreading melanoma (SSM)-like component with maturation to a small cell, but still atypical, dermal component; we termed these “maturing naevoid” melanomas. We showed that papillomatous and maturing naevoid melanomas also have differing immunochemical profiles. Preliminary clinical follow-up suggested different outcomes for these two naevoid melanoma types. Conclusions Melanomas that have been classified as naevoid melanomas comprise two types with distinct clinical, histopathologic and immunohistochemical features that may also be prognostically significant. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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