Pituitary–testicular function in acromegalic and hypophysectomized patients
| Autor: | Peter A. Rasmussen, Jörgen Lindholm, O. Korsgaard |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Hypophysectomy Pituitary disorder medicine.medical_treatment Clinical Biochemistry Chromophobe cell Biochemistry Gonadotropin-Releasing Hormone Follicle-stimulating hormone Basal (phylogenetics) Internal medicine Testis Acromegaly medicine Humans Testosterone Adenoma Chromophobe business.industry Hypogonadism General Medicine Luteinizing Hormone medicine.disease Testicular function Endocrinology Pituitary Gland Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Clinical Investigation. 7:141-143 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1977.tb01587.x |
| Popis: | Serum testosterone, LH, and FSH before and after i.v. injection of LHRH were studied in ten acromegalic men and in twenty-one males after hypophysectomy. Controls were normal men matched according to age. Compared to the controls, basal FSH was slightly higher and basal LGH slightly lower in the untreated acromegalics. The differences were not statistically significant. Serum testosterone and the ratio between basal FSH and LH were significantly lower in the patients. Following hypophysectomy because of acromegaly, the values were essentially unchanged. Hypophysectomy because of a functionless chromophobe adenoma resulted in a significantly lower maximum value of LH but not of FSH after LHRH. The results show that hypogonadism in acromegaly might be a result of imbalance between LH and FSH. They furthermore demonstrate that testing the pituitary-testicular function with LHRH in patients with pituitary disorders seems to be of limited value. |
| Databáze: | OpenAIRE |
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