Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
| Autor: | Malinowska-Borowska Jolanta, Mroczek Alina, Głogowska-Gruszka Anna, Rozentryt Piotr, Hudzik Bartosz, Gąsior Mariusz, Duda Sylwia, Buczkowska Marta, Partyka Robert, Niedziela Jacek |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty chemistry.chemical_element Renal function Kaplan-Meier Estimate Gastroenterology Article serum phosphorus Risk Factors Internal medicine Risk of mortality Humans Medicine TX341-641 Risk factor Natriuretic Peptides Proportional Hazards Models Heart Failure Nutrition and Dietetics Ejection fraction Nutrition. Foods and food supply business.industry Phosphorus Hazard ratio medicine.disease chronic heart failure chemistry Relative risk Heart failure all-cause mortality Female prognosis business Biomarkers Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 4004, p 4004 (2021) Nutrients Volume 13 Issue 11 |
| ISSN: | 2072-6643 |
| Popis: | Higher serum phosphorus has detrimental health effects. Even high-normal rage sP is associated with worse outcomes. The relationship of serum phosphorus with prognostic markers in heart failure remains unclear. We investigated the association of serum phosphorus with heart failure prognostic factors and risk of mortality related to serum phosphorus. In 1029 stable heart failure patients, we investigated the distribution of markers of more advanced heart failure stage across quintiles of serum phosphorus and estimated the relative risk of mortality in comparison to reference. Higher serum phosphorus levels sP were associated with markers of a worse outcome. The best survival was observed in low-normal serum levels. The unadjusted hazard ratio for mortality increased toward higher phosphorus quintiles but not to lower levels of sP. The correction for age, sex, BMI, percent weight loss, inflammation, kidney function, and LVEF did not modify the risk profile substantially. The adjustment for NYHA, natriuretic peptides, serum sodium, and treatment characteristics broke down the risk relationship completely. A higher serum phosphorus is associated with markers of a more risky profile of heart failure. Elevated serum levels of phosphorus sP does not provide independent prognostic information beyond the strongest markers of the severity of the syndrome. The potential involvement of higher serum phosphorus as a mediator in the pathophysiology of heart failure warrants further study. |
| Databáze: | OpenAIRE |
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