Comparison of histamine release in cord blood and adult blood
| Autor: | B. W. Nielsen, T. M. Engberg, T. Bjerke, Peter Oluf Schiøtz |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Allergy Aging Immunology Pharmacology toxicology Stimulation Toxicology Histamine Release chemistry.chemical_compound Internal medicine Concanavalin A Medicine Pharmacology (medical) Pharmacology biology business.industry Immunoglobulin E medicine.disease Fetal Blood Antibodies Anti-Idiotypic Basophils N-Formylmethionine Leucyl-Phenylalanine Endocrinology chemistry Cord blood Anesthesia Passive sensitization biology.protein business Histamine |
| Zdroj: | Agents and actions. 33(1-2) |
| ISSN: | 0065-4299 |
| Popis: | Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood. |
| Databáze: | OpenAIRE |
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