Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways
| Autor: | Yang Chang Wu, Wei Chien Huang, Te-Mao Li, Chih-Hsin Tang, Hsiang-Ping Lee, Chin-Jung Hsu, Shan-Chi Liu, Bo-Cheng Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
MAPK/ERK pathway
rheumatoid arthritis lcsh:Immunologic diseases. Allergy il-1β Immunology soya-cerebroside 01 natural sciences Proinflammatory cytokine chemistry.chemical_compound 0404 agricultural biotechnology il-8 Cordyceps militaris il-6 medicine Synovial fluid Interleukin 8 lcsh:Agriculture (General) Interleukin 6 biology Chemistry 010401 analytical chemistry food and beverages NF-κB 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040401 food science lcsh:S1-972 0104 chemical sciences biology.protein Cancer research lcsh:RC581-607 Agronomy and Crop Science Infiltration (medical) Food Science |
| Zdroj: | Food and Agricultural Immunology, Vol 31, Iss 1, Pp 740-750 (2020) |
| ISSN: | 1465-3443 0954-0105 |
| Popis: | Rheumatoid arthritis (RA) is characterised by the infiltration of a number of proinflammatory cytokines into synovial fluid. Soya-cerebroside, an extract from Cordyceps militaris, inhibits synovial inflammation and reduces cartilage damage in an osteoarthritis model, although the role of soya-cerebroside in inflammatory cytokine expression in RA is uncertain. In this study, Gene Expression Omnibus (GEO) database records revealed higher levels of interleukin (IL)-1β, IL-6 and IL-8 in RA tissue compared with normal tissue. Elevated levels of these inflammatory cytokines were also higher in mice with collagen-induced arthritis (CIA) than in control mice. Soya-cerebroside effectively inhibited IL-1β, IL-6 and IL-8 expression in RA synovial fibroblasts, apparently by inhibiting the ERK, NF-κB and AP-1 signalling pathways. This anti-inflammatory agent shows promise for the treatment of RA. |
| Databáze: | OpenAIRE |
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