Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food
| Autor: | Deanna McCarthy, Harry A. Oken, Dror Rom, Linda M. Arterburn, Gloria Chung, Eileen Bailey-Hall, James P Hoffman, Jacqueline Hamersley |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Erythrocytes genetic structures Adolescent Docosahexaenoic Acids Phospholipid Capsules Bioequivalence Biochemistry Placebos chemistry.chemical_compound Dietary Fats Unsaturated Double-Blind Method Humans Food science Fortified Food Phospholipids Aged chemistry.chemical_classification Chromatography Arachidonic Acid Organic Chemistry food and beverages Fatty acid Eukaryota Cell Biology Middle Aged Eicosapentaenoic acid Bioavailability chemistry Eicosapentaenoic Acid Therapeutic Equivalency Docosahexaenoic acid Dietary Supplements Food Fortified Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Arachidonic acid Female |
| Zdroj: | Lipids. 42(11) |
| ISSN: | 0024-4201 |
| Popis: | Docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid, is important for eye and brain development and ongoing visual, cognitive, and cardiovascular health. Unlike fish-sourced oils, the bioavailability of DHA from vegetarian-sourced (algal) oils has not been formally assessed. We assessed bioequivalence of DHA oils in capsules from two different algal strains versus bioavailability from an algal-DHA-fortified food. Our 28-day randomized, placebo-controlled, parallel group study compared bioavailability of (a) two different algal DHA oils in capsules ("DHASCO-T" and "DHASCO-S") at doses of 200, 600, and 1,000 mg DHA per day (n = 12 per group) and of (b) an algal-DHA-fortified food (n = 12). Bioequivalence was based on changes in plasma phospholipid and erythrocyte DHA levels. Effects on arachidonic acid (ARA), docosapentaenoic acid-n-6 (DPAn-6), and eicosapentaenoic acid (EPA) were also determined. Both DHASCO-T and DHASCO-S capsules produced equivalent DHA levels in plasma phospholipids and erythrocytes. DHA response was dose-dependent and linear over the dose range, plasma phospholipid DHA increased by 1.17, 2.28 and 3.03 g per 100 g fatty acid at 200, 600, and 1,000 mg dose, respectively. Snack bars fortified with DHASCO-S oil also delivered equivalent amounts of DHA on a DHA dose basis. Adverse event monitoring revealed an excellent safety and tolerability profile. Two different algal oil capsule supplements and an algal oil-fortified food represent bioequivalent and safe sources of DHA. |
| Databáze: | OpenAIRE |
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