Evaluation of a Helicobacter pylori Stool Antigen Test for the Diagnosis and Follow-Up of Infections in Children
| Autor: | Frédéric Gottrand, D. Guimber, C. Lenaerts, P. S. Ganga-Zandzou, Claire Spyckerelle, M. O. Husson, C. Rolland, Nicolas Kalach |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Adolescent Spirillaceae Gastroenterology Helicobacter Infections Feces Medical microbiology Pharmacotherapy Antigen Internal medicine medicine Humans Child Antigens Bacterial Helicobacter pylori medicine.diagnostic_test biology business.industry Infant General Medicine biology.organism_classification Endoscopy Infectious Diseases Evaluation Studies as Topic Child Preschool Immunoassay Immunology Female Reagent Kits Diagnostic Bacterial antigen business Follow-Up Studies |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 19:787-789 |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | The aim of this study was to evaluate the performance of a newly developed enzyme immunoassay kit (HpSA) for detecting Helicobacter pylori antigens in the stool of children. This study was comprised of 58 children referred to various endoscopy units for evaluation of gastrointestinal symptoms and upper gastroduodenal endoscopy and 11 children for post-therapy follow-up. In the first group, 23 children were diagnosed as positive for Helicobacter pylori using bacteriological and/or histological methods. Stool antigens were detected in 20 of these positive patients, for a sensitivity of 86.9% and a negative predictive value of 91.9%. Since only one false-positive reaction was observed with the HpSA kit, the specificity was 97.1% and the positive predictive value 95.2%. Results obtained for post-therapy follow-up were also promising. The HpSA assays were negative for the eight children whose infections were eradicated after therapy, and a positive result was obtained for two of three patients who had a persistent infection. |
| Databáze: | OpenAIRE |
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