Antagonism between parasites within snail hosts impacts the transmission of human schistosomiasis
| Autor: | Eric S. Loker, Larissa C Anderson, Martina R. Laidemitt, Helen J. Wearing, Martin W. Mutuku, Gerald M. Mkoji |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
QH301-705.5 Science 030231 tropical medicine Zoology Biomphalaria Human pathogen Snail Models Biological General Biochemistry Genetics and Molecular Biology Host-Parasite Interactions 03 medical and health sciences 0302 clinical medicine Biomphalaria pfeifferi biology.animal schistosomiasis parasitic diseases Animals Humans Parasite hosting Parasites trematode biodiversity Biology (General) neglected tropical diseases Ecology General Immunology and Microbiology biology General Neuroscience fungi Biodiversity General Medicine Schistosoma mansoni biology.organism_classification Kenya antagonism Epidemiology and Global Health 030104 developmental biology Vector (epidemiology) Human parasite Medicine Cattle Trematoda Other pastoralism Research Article |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | Human disease agents exist within complex environments that have underappreciated effects on transmission, especially for parasites with multi-host life cycles. We examined the impact of multiple host and parasite species on transmission of the human parasite Schistosoma mansoni in Kenya. We show S. mansoni is impacted by cattle and wild vertebrates because of their role in supporting trematode parasites, the larvae of which have antagonistic interactions with S. mansoni in their shared Biomphalaria vector snails. We discovered the abundant cattle trematode, Calicophoron sukari, fails to develop in Biomphalaria pfeifferi unless S. mansoni larvae are present in the same snail. Further development of S. mansoni is subsequently prevented by C. sukari’s presence. Modeling indicated that removal of C. sukari would increase S. mansoni-infected snails by two-fold. Predictable exploitation of aquatic habitats by humans and their cattle enable C. sukari to exploit S. mansoni, thereby limiting transmission of this human pathogen. |
| Databáze: | OpenAIRE |
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