Age-Related Standards for Total Lymphocyte, CD4+ and CD8+ T Cell Counts in Children Born in Europe
| Autor: | Giaquinto, Carlo, Rampon, O, Giacomet, V, DE ROSSI, Anita, GROSCH WORNER, I, Mok, J, Bates, I, DE JOSE, I, Hawkins, F, GARCIA RODRIGUEZ MC, DE GUEVARA, L, Pena, Jm, Garcia, Jg, Lopez, Jra, ASENSI BOTET, F, Otero, Mc, PEREZ TAMARIT, D, Orti, A, SAN MIGUEL MJ, Scherpbier, H, Kreyenbroek, M, Boer, K, Bohlin, Ab, Belfrage, E, Naver, L, Levy, J, Hainaut, M, Peltier, A, Goetghebuer, T, Barlow, P, Ferrazin, A, DE MARIA, A, Gotta, C, Mur, A, LOPEZ VILCHEZ MA, Paya, A, Carreras, R, Valerius, Nh, Niemec, T, Marczynska, M. |
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| Rok vydání: | 2005 |
| Předmět: |
lymphocytes
Microbiology (medical) Lymphocyte Human immunodeficiency virus (HIV) Black People HIV Infections lymphocytes CD4(+) cells CD8(+) cells human immunodeficiency virus CD8-Positive T-Lymphocytes medicine.disease_cause White People Acquired immunodeficiency syndrome (AIDS) Pregnancy Age related medicine Humans Cytotoxic T cell Lymphocyte Count Pregnancy Complications Infectious Child Prospective cohort study Total Lymphocyte Counts human immunodeficiency virus business.industry Age Factors Infant Newborn Infant CD8(+) cells medicine.disease CD4 Lymphocyte Count Europe CD4(+) cells Infectious Diseases medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology HIV-1 Female business Demography |
| Zdroj: | Pediatric Infectious Disease Journal. 24:595-600 |
| ISSN: | 0891-3668 |
| Popis: | Objective Currently used reference values for immunologic markers in children are largely derived from cross-sectional data from historic, small sample size studies in predominantly white children. There is a lack of reliable age-related standards for immunologic markers, such as CD4+ cell counts, in particular in black children whose values according to recent reports may differ from those in white children. Standards are essential for diagnosing and monitoring childhood diseases such as pediatric human immunodeficiency virus (HIV) infection. Design Prospective cohort study with data on 1781 uninfected children born to HIV-infected mothers in the European Collaborative Study. Methods Age-related standards (centiles) for immunologic markers (CD4+ and CD8+ cell counts and total lymphocyte counts) up to 5 years in black and up to 10 years in white children were constructed using Generalized Additive Models for Location, Scale and Shape method, which allows for variability and skewness of the data. The optimal model was chosen according to the Akaike Information Criterion. Results Patterns and values of total lymphocyte, CD4+ and CD8+ cell counts varied with age, especially in the first 3 years of life, but less so thereafter. Values of all 3 immunologic markers were substantially and significantly lower in black than in white children of the same age. Conclusions We present age-related standards separately for black and white children to aid clinicians in the monitoring of childhood diseases. These standards may also contribute to the decision on an accurate cutoff for CD4+ cell counts for initiating treatment of HIV-infected children. |
| Databáze: | OpenAIRE |
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