Nasal pleomorphic adenoma with skeletal muscle differentiation: potential misdiagnosis as rhabdomyosarcoma
| Autor: | John K. Chan, Vat-Chong Sin, Polly W.Y. Lam |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Biopsy Nasopharyngeal neoplasm Adenoma Pleomorphic Biology Pathology and Forensic Medicine Desmin Pleomorphic adenoma Diagnosis Differential Rhabdomyosarcoma medicine Atypia Carcinoma Biomarkers Tumor Humans Muscle Skeletal Cartilage Myoepithelial cell Skeletal muscle Nasopharyngeal Neoplasms Neoplasms Second Primary medicine.disease Immunohistochemistry medicine.anatomical_structure Female Neoplasm Recurrence Local |
| Zdroj: | Human pathology. 28(11) |
| ISSN: | 0046-8177 |
| Popis: | Pleomorphic adenoma can show diverse lines of differentiation in the epithelial and myoepithelial elements, such as cartilage, bone, and fat. Myoid differentiation, however, has not been documented. We report an unusual case of nasal pleomorphic adenoma which shows focal skeletal muscle differentiation. The tumor was discovered only after successful radiation therapy for an undifferentiated carcinoma of the nasopharynx. Apart from being of morphological interest, the presence of cells with skeletal muscle differentiation also raises the practical issue of possible confusion with rhabdomyosarcoma in a biopsy. The distinguishing features are lack of cytological atypia and presence of a neoplastic glandular element. |
| Databáze: | OpenAIRE |
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