Dynamic contrast-enhanced magnetic resonance imaging for pretreatment prediction of early chemo-radiotherapy response in larynx and hypopharynx carcinoma
| Autor: | Xinyi Chen, Chunwu Zhou, Wei Guo, Yanfeng Zhao, Meng Lin, Lin Li, Xinming Zhao, Lei Hu, Liang Yang, Dehong Luo |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Larynx medicine.medical_specialty chemo-radiotherapy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Time intensity curve Laryngeal Neoplasms Chemo-radiotherapy Hypopharyngeal Neoplasms medicine.diagnostic_test business.industry Cancer Magnetic resonance imaging Chemoradiotherapy Middle Aged Image Enhancement Prognosis medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Surgery Dynamic contrast Treatment Outcome medicine.anatomical_structure ROC Curve Oncology Response Evaluation Criteria in Solid Tumors Area Under Curve 030220 oncology & carcinogenesis dynamic contrast-enhanced magnetic resonance imaging semi-quantitative parameters Clinical Research Paper larynx and hypopharynx carcinoma Nuclear medicine business |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Wei Guo 1 , Dehong Luo 1 , Xinyi Chen 2 , Meng Lin 1 , Lin Li 1 , Yanfeng Zhao 1 , Liang Yang 1 , Lei Hu 1 , Xinming Zhao 1 and Chunwu Zhou 1 1 Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing, China 2 Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Correspondence to: Dehong Luo, email: // Keywords : chemo-radiotherapy, dynamic contrast-enhanced magnetic resonance imaging, larynx and hypopharynx carcinoma, semi-quantitative parameters Received : July 18, 2016 Accepted : October 22, 2016 Published : October 27, 2016 Abstract Purpose: This study is to investigate the use of dynamic contrast-enhanced magnetic resonance imaging in predicting early response to CRT (chemo-radiotherapy) in patients with larynx and hypopharynx carcinoma from primary tumors. Method: Sixty-two patients with larynx and hypopharynx carcinoma underwent two DCE-MRI studies: a baseline exam before any treatment and a post-treatment exam 3 weeks after CRT. At the end of treatment, patients were classified as responders, or non-responders according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST). The time intensity curves (TIC) were extracted and processed to obtain time to peak (TTP), maximum slope of increase (MSI), maximum slope of decrease (MSD) and positive enhancement integral (PEI), and the semi-quantitative MRI parameters were compared and analyzed between the two groups. Results: Fifty-four and 8 patients were included the responder and non-responder groups. It was observed that the MSI, MSD, and PEI were significantly lower post-treatment than pre-treatment( P < 0.05). The pretreatment MSI, MSD, and PEI parameters of responders were significantly higher than those of non-responders ( P < 0.05). The post-treatment MSI, MSD, and PEI parameters of responders were significantly lower than those of non-responders ( P < 0.05). Based on ROC curve analysis, at a threshold of 154.81 for pretreatment MSI, the corresponding AUC, sensitivity, and specificity were 0.882, 89.3% and 73.5%, respectively. Conclusion: The semi-quantitative DCE-MRI may aid in the prediction of early response to CRT in patients with larynx and hypopharynx carcinoma. |
| Databáze: | OpenAIRE |
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