Relationship of Thyroid Function with Obesity and Type 2 Diabetes in Euthyroid Tunisian Subjects
| Autor: | M. Ammar, Hafawa Abid, Slim Jarboui, Amel Benammar Elgaaied, F. Bchir, Rym Berhouma, Isabelle Seugnet, Hajer Guissouma, Kamel Rouissi, Marie-Stéphanie Clerget-Froidevaux, Soumaya Kouidhi, Barbara A. Demeneix |
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| Přispěvatelé: | Université de Tunis El Manar (UTM), Service de chirurgie viscérale, Hôpital Charles Nicolle [Tunis], Evolution des régulations endocriniennes (ERE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), This work was supported by a 210 PHC-Utique program/CMCU grant no. 06G0910 for Soumaya Kouidhi and EU contract no. 018652 'CRESCENDO'., European Project: 018652,CRESCENDO, Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN) |
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male endocrine system diseases [SDV]Life Sciences [q-bio] Thyroid Gland Thyrotropin Type 2 diabetes Thyroid Function Tests 0302 clinical medicine Endocrinology MESH: Metabolic Syndrome X MESH: Obesity Insulin Euthyroid Metabolic Syndrome 0303 health sciences MESH: Middle Aged medicine.diagnostic_test TSH General Medicine [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Middle Aged MESH: Insulin Resistance MESH: Thyrotropin Female Thyroid function MESH: Tunisia hormones hormone substitutes and hormone antagonists MESH: Diabetes Mellitus Type 2 endocrine system medicine.medical_specialty Tunisia 030209 endocrinology & metabolism MESH: Insulin Thyroid function tests 03 medical and health sciences Insulin resistance Thyroid-stimulating hormone Internal medicine Diabetes mellitus medicine Humans Obesity 030304 developmental biology MESH: Thyroid Function Tests MESH: Humans business.industry MESH: Thyroxine medicine.disease MESH: Male MESH: Thyroid Gland Thyroxine Diabetes Mellitus Type 2 MESH: Blood Glucose Insulin Resistance Metabolic syndrome business MESH: Female |
| Zdroj: | Endocrine Research Endocrine Research, 2013, 38 (1), pp.15-23. ⟨10.3109/07435800.2012.699987⟩ Endocrine Research, Taylor & Francis, 2013, 38 (1), pp.15-23. ⟨10.3109/07435800.2012.699987⟩ |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435800.2012.699987 |
| Popis: | International audience; Objectives. Although a relationship between obesity and metabolic consequences with thyroid function has been reported, the underlying pathogenesis is not completely known. In the current study, we evaluated the thyroid function in obese and/or diabetic patients compared to healthy normal weight peers, exploring the possible association between components of metabolic syndrome and thyroid function parameters. Methods. We recruited 108 subjects (56 male and 52 female). In all subjects, thyroid stimulating hormone (TSH), free thyroxine (FT4), fasting plasma levels of insulin and glucose, homeostasis model assessment for insulin resistance, and obesity parameters were assessed. Results. We found that circulating levels of TSH and FT4 were significantly increased in overweight and obese subjects. However, the data do not reveal any change of these hormones in diabetics. Multivariate linear regression analysis showed that TSH was directly associated with both obesity and insulin resistance parameters (p < 0.05). FT4 was negatively associated only with obesity parameters (p < 0.05). Conclusions. Our data strongly support that the changes of thyroid hormones may be influenced by adiposity and its metabolic consequences, such as insulin resistance. This relationship can be explained by a cross talk between adipose tissue release and thyroid function. Nevertheless, metformin treatment seems to affect thyroid function in diabetic patients by maintaining plasma thyrotropin levels to subnormal levels. |
| Databáze: | OpenAIRE |
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