Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1
| Autor: | Yingxian Sun, Daniel T. Eitzman, Hui Wang, Kyle Kleiman, Qian Wang, Jessica Venugopal, Jintao Wang, Chiao Guo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Continuous infusion lcsh:Medicine Blood Pressure 030204 cardiovascular system & hematology Article law.invention 03 medical and health sciences Mice 0302 clinical medicine law Internal medicine medicine Animals Vasoconstrictor Agents lcsh:Science Mice Knockout Multidisciplinary Membrane Glycoproteins integumentary system business.industry Angiotensin II lcsh:R Interleukin-17 Ligand (biochemistry) Haematopoiesis Disease Models Animal 030104 developmental biology Blood pressure Endocrinology Pressor response Hypertension Recombinant DNA lcsh:Q P-selectin glycoprotein ligand-1 business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Identification of inflammatory mediators that regulate the vascular response to vasopressor molecules may aid in the development of novel therapeutic agents to treat or prevent hypertensive vascular diseases. Leukocytes have recently been shown to be capable of modifying blood pressure responses to vasopressor molecules. The purpose of this study was to test the hypothesis that deficiency of the leukocyte ligand, Psgl-1, would reduce the pressor response to angiotensin II (Ang II). Mice deficient in Psgl-1 (Psgl-1−/−) along with wild-type (WT) controls were treated for 2 weeks with a continuous infusion of Ang II. No differences in blood pressure between the groups were noted at baseline, however after 5 days of Ang II infusion, systolic blood pressures were higher in WT compared to Psgl-1−/− mice. The pressor response to acute administration of high dose Ang II was also attenuated in Psgl-1−/− compared to WT mice. Chimeric mice with hematopoietic deficiency of Psgl-1 similarly showed a reduced pressor response to Ang II. This effect was associated with reduced plasma interleukin-17 (IL-17) levels in Psgl-1−/− mice and the reduced pressor response was restored by administration of recombinant IL-17. In conclusion, hematopoietic deficiency of Psgl-1 attenuates Ang II-induced hypertension, an effect that may be mediated by reduced IL-17. |
| Databáze: | OpenAIRE |
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