Women using bleach for home cleaning are at increased risk of non-allergic asthma
| Autor: | Nicole Le Moual, Bobette Matulonga, Alfred Bernard, Valérie Siroux, Rachel Nadif, Jan-Paul Zock, Marta Rava, Bénédicte Leynaert, Isabelle Pin, Orianne Dumas |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty genetic structures Bleach Neutrophils Respiratory System Bronchial Provocation Tests Allergic sensitization Bleaching Agents 03 medical and health sciences 0302 clinical medicine Risk Factors Occupational Exposure Internal medicine Epidemiology Hypersensitivity medicine Humans 030212 general & internal medicine Risk factor Asthma business.industry Household Products Middle Aged medicine.disease Confidence interval respiratory tract diseases Surgery Occupational Diseases Household Work Chronic cough 030228 respiratory system Bronchial hyperresponsiveness Case-Control Studies Female sense organs Bronchial Hyperreactivity medicine.symptom business |
| Zdroj: | Respiratory Medicine. 117:264-271 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2016.06.019 |
| Popis: | Background Bleach is widely used for household cleaning. Although it is recognized that occupational use of bleach may have adverse respiratory health effects, it is unknown whether common domestic use of bleach may be a risk factor for asthma. Aim To assess whether the domestic use of bleach for home cleaning is associated with asthma and other respiratory outcomes. Methods Questionnaire-based information on respiratory symptoms and cleaning habits and data from skin prick-tests, bronchial responsiveness challenge and white blood cells were analyzed in 607 women participating in the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Bleach use was evaluated in 3 categories ( Results Overall, 37% of the women reported using bleach weekly. Women using bleach frequently (11%) were more likely to have current asthma as compared to non-users (adjusted Odds-Ratio (aOR) = 1.7; 95% Confidence Interval (95%CI) 1.0–3.0). Among women with asthma, frequent use of bleach was significantly associated with higher blood neutrophil cell counts. Bleach use was significantly associated with non-allergic asthma (aOR 3.3; 95%CI 1.5–7.1), and more particularly with non-allergic adult-onset asthma (aOR 4.9; 95%CI 2.0–11.6). Consistently, among women without allergic sensitization, significant positive associations were found between use of bleach and bronchial hyperresponsiveness, asthma like-symptoms and chronic cough. No association was observed for allergic asthma. Conclusions Frequent use of bleach for home-cleaning is associated with non-allergic adult-onset asthma, elevated neutrophil counts and lower-airway symptoms in women. |
| Databáze: | OpenAIRE |
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