Early Change of Extracellular Matrix and Diastolic Parameters in Metabolic Syndrome
| Autor: | Bruno Schneider de Araujo, Nadine Oliveira Clausell, Murilo Foppa, Adriana Macari, Maurício Junges, Luis Eduardo Paim Rohde, Bruce Bartholow Duncan, Beatriz Graeff Santos Seligman, Angela B. S. Santos, Daiane Silvello |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart Ventricles Diastole Risk Assessment Risk Factors Internal medicine medicine Humans Matrix metalloproteinase inhibitors Letter to the Editor Ultrasonography Metabolic Syndrome Tissue Inhibitor of Metalloproteinase-1 business.industry Matrix metalloproteinase 9 Original Articles Extracellular matrix Middle Aged medicine.disease Molecular biology C-Reactive Protein Cross-Sectional Studies Endocrinology Matrix Metalloproteinase 9 Cardiovascular Diseases Case-Control Studies Diastole / physiopathology Female Metabolic X Syndrome Insulin Resistance Matrix Metalloproteinase 1 Metabolic syndrome Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Arquivos Brasileiros de Cardiologia |
| ISSN: | 0066-782X |
| Popis: | Background Metabolic syndrome (MS) is associated with increased cardiovascular risk. It is not clear whether myocardial changes showed in this syndrome, such as diastolic dysfunction, are due to the systemic effects of the syndrome, or to specific myocardial effects. Objectives Compare diastolic function, biomarkers representing extracellular matrix activity (ECM), inflammation and cardiac hemodynamic stress in patients with the MS and healthy controls. Methods MS patients (n = 76) and healthy controls (n=30) were submitted to a clinical assessment, echocardiographic study, and measurement of plasma levels of metalloproteinase-9 (MMP9), tissue inhibitor of metalloproteinase-1 (TIMP1), ultrasensitive-reactive-C-Protein (us-CRP), insulin resistance (HOMA-IR) and natriuretic peptide (NT-proBNP). Results MS group showed lower E' wave (10.1 ± 3.0 cm/s vs 11.9 ± 2.6 cm/s, p = 0.005), increased A wave (63.4 ± 14.1 cm/s vs. 53.1 ± 8.9 cm/s; p < 0.001), E/E' ratio (8.0 ± 2.2 vs. 6.3 ± 1.2; p < 0.001), MMP9 (502.9 ± 237.1 ng / mL vs. 330.4±162.7 ng/mL; p < 0.001), us-CRP (p = 0.001) and HOMA-IR (p < 0.001), but no difference for TIMP1 or NT-proBNP levels. In a multivariable analysis, only MMP9 was independently associated with MS. Conclusion MS patients showed differences for echocardiographic measures of diastolic function, ECM activity, us-CRP and HOMA-IR when compared to controls. However, only MMP9 was independently associated with the MS. These findings suggest that there are early effects on ECM activity, which cannot be tracked by routine echocardiographic measures of diastolic function. |
| Databáze: | OpenAIRE |
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