Postoperative C-reactive Protein Is a Predictive Biomarker for Survival After Non-small Cell Lung Cancer Resection
| Autor: | Masakazu Sugaya, Shuichi Shinohara, Masaki Matsuo, Kazuhiko Machida, Makoto Nakagawa, Takamitsu Onitsuka, Ryo Otsuki |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Multivariate analysis Lung Neoplasms Subgroup analysis Kaplan-Meier Estimate Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Non-Small-Cell Lung Medicine Humans Prognostic biomarker Postoperative Period Lung cancer Pathological Aged Neoplasm Staging biology business.industry Hazard ratio C-reactive protein General Medicine medicine.disease Prognosis Survival Rate C-Reactive Protein Oncology 030220 oncology & carcinogenesis biology.protein Female Non small cell business Biomarkers |
| Zdroj: | Anticancer research. 39(4) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND/AIM Preoperative C-reactive protein (CRP) is well recognized as a prognostic factor of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the prognostic impact of postoperative CRP in patients with NSCLC following lung resection. PATIENTS AND METHODS We retrospectively reviewed 336 patients with NSCLC treated with lung resection. CRP levels were measured at postoperative week 6 (CRP6w; range: 4-8 weeks). Patients were divided into two groups based on CRP6w median value (5.0 mg/l); the 5-year overall survival (OS) as well as the recurrence-free survival (RFS) was evaluated in both groups. RESULTS Five-year OS and RFS were worse in the high-CRP6w group than in the low-CRP6w group (62.9% vs. 82.9%; p |
| Databáze: | OpenAIRE |
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