Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle
| Autor: | M. C. Barrett, Doris J. Taylor, Russell Lane, R. Lodi, Graham J. Kemp |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Phosphocreatine Biopsy Intracellular pH Adenosine Triphosphate Forearm Reference Values Internal medicine Chronic fatigue syndrome Humans Medicine Lactic Acid Muscle Skeletal Genetics (clinical) Fatigue Syndrome Chronic business.industry Genetic Variation Nuclear magnetic resonance spectroscopy Middle Aged medicine.disease Surgery Adenosine Diphosphate medicine.anatomical_structure Neurology Pediatrics Perinatology and Child Health Moderate exercise Cardiology Female Neurology (clinical) business |
| Zdroj: | Neuromuscular Disorders. 8:204-209 |
| ISSN: | 0960-8966 |
| DOI: | 10.1016/s0960-8966(98)00021-2 |
| Popis: | It has been shown previously that some patients with chronic fatigue syndrome show an abnormal increase in plasma lactate following a short period of moderate exercise, in the sub-anaerobic threshold exercise test (SATET). This cannot be explained satisfactorily by the effects of 'inactivity' or 'deconditioning', and patients with abnormal lactate responses to exercise (SATET +ve) have been found to have significantly fewer Type 1 muscle fibres in quadriceps biopsies than SATET -ve patients. We performed phosphorus magnetic resonance spectroscopy on forearm muscles of 10 SATET +ve patients, 9 SATET -ve patients and 13 sedentary volunteers. There were no differences in resting spectra between these groups but at the end of exercise, intracellular pH in the SATET +ve patients was significantly lower than in both the SATET -ve cases and controls (P0.03), and the SATET +ve patients also showed a significantly lower ATP synthesis rate during recovery (P0.01), indicating impaired mitochondrial oxidative phosphorylation. These observations support other evidence which indicates that chronic fatigue syndrome is a heterogeneous disorder, and confirms the view that some chronic fatigue syndrome patients have a peripheral component to their fatigue. |
| Databáze: | OpenAIRE |
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