Measurements of body surface area and volume in laboratory rabbits (New Zealand White rabbits) using a computed tomography scanner
| Autor: | Kazuro Miyahara, Mifumi Kawabe, Masafumi Miyoshi, Tsuneo Koike, Takahiko Nagase, Tadashi Itoh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Body Surface Area Original 040301 veterinary sciences rabbit Computed tomography Body weight General Biochemistry Genetics and Molecular Biology Sphericity 0403 veterinary science 03 medical and health sciences Animal science Animals laboratory Animals Laboratory Computed tomography scanner medicine Animals New zealand white Body surface area General Veterinary medicine.diagnostic_test computed tomography 04 agricultural and veterinary sciences General Medicine CT scanner 030104 developmental biology Tomography x ray computed CT image Female Animal Science and Zoology Rabbits Tomography X-Ray Computed |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.18-0028 |
| Popis: | application/pdf The body surface area (BSA) of an organism is one of the important parameters for evaluating physiological functions. In drug development, normalization by BSA is an appropriate method for extrapolating doses between species. The BSA of animals has generally been estimated by multiplying the k value by 2/3 of the power of the body weight (BW) (Meeh’s formula). In mathematics, if it is assumed that the density and body shape of the animals are essentially constant, the BSA is proportional to BW2/3. In this study, we measured the BSA and volume (V) of 72 laboratory rabbits (48 males and 24 females of New Zealand White rabbits [NZW]), using a computed tomography scanner. After BSA and V determination, the k value, density, and sphericity were calculated. We analyzed variations in the k value, density, and body shape of laboratory rabbits. The mean k value of the 72 NZW was 11.0. We advocate using Meeh’s formula, as follows, for estimating BSA of laboratory rabbits (NZW): 100 × BSA [m2] = 11.0 × BW [kg]2/3. © 2018 Japanese Association for Laboratory Animal Science. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|