Prolonged treatment of fair-skinned mice with topical forskolin causes persistent tanning and UV protection
| Autor: | Timothy L. Scott, Osama Abona-Ama, Kazumasa Wakamatsu, John A. D'Orazio, Malinda Spry, Jillian C. Vanover, Shosuke Ito |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Time Factors Erythema Ultraviolet Rays Administration Topical Radiation-Protective Agents Skin Pigmentation Dermatology Melanocyte Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Mice visual_art.visual_artist Sunbathing Internal medicine Skin Physiological Phenomena medicine Animals Receptor Uv protection Melanins Forskolin integumentary system Epidermis (botany) Body Weight Colforsin Organ Size medicine.anatomical_structure Endocrinology Oncology chemistry Liver visual_art Melanocytes medicine.symptom Receptor Melanocortin Type 1 Prolonged treatment |
| Zdroj: | Pigment cellmelanoma research. 22(2) |
| ISSN: | 1755-1471 |
| Popis: | We previously reported that topical application of forskolin to the skin of fair-skinned MC1R-defective mice with epidermal melanocytes resulted in accumulation of eumelanin in the epidermis and was highly protective against UV-mediated cutaneous injury. In this report, we describe the long-term effects of chronic topical forskolin treatment in this animal model. Forskolin-induced eumelanin production persisted through 3 months of daily applications, and forskolin-induced eumelanin remained protective against UV damage as assessed by minimal erythematous dose (MED). No obvious toxic changes were noted in the skin or overall health of animals exposed to prolonged forskolin therapy. Body weights were maintained throughout the course of topical forskolin application. Topical application of forskolin was associated with an increase in the number of melanocytes in the epidermis and thickening of the epidermis due, at least in part, to an accumulation of nucleated keratinocytes. Together, these data suggest in this animal model, short-term topical regular application of forskolin promotes eumelanin induction and that over time, topical forskolin treatment is associated with persistent melanization, epidermal cell accumulation, and skin thickening. |
| Databáze: | OpenAIRE |
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