COVID-19 vaccination in autoimmune diseases (COVAD) study: vaccine safety and tolerance in rheumatoid arthritis

Autor: Naveen, R, Ioannis, Parodis, Mrudula, Joshi, Parikshit, Sen, Julius, Lindblom, Vishwesh, Agarwal, James, B Lilleker, Ai Lyn Tan, Arvind, Nune, Samuel Katsuyuki Shinjo, Babur, Salim, Nelly, Ziade, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Miguel, A Saavedra, Jessica, Day, Ashima, Makol, Oliver, Distler, Hector, Chinoy, COVAD Study Group, Vikas Agarwal, Rohit Aggarwal, Latika, Gupta, Elena Nikiphorou The COVAD study group collaborators are: Bhupen Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Pandya, Sapan C., Rakesh Kumar Pilania, Aman, Sharma, Manoj, M, Vikas, Gupta, Kavadichanda, Chengappa G., Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Pandey, Arun Kumar R., Kunal, Chandwar, Sinan, Kardes¸, Do¨ndu¨ U¨ sku¨ dar Cansu, Minchul, Kim, Tulika, Chatterjee, Pauling, John D., Chris, Wincup, Lorenzo, Cavagna, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Marcin, Milchert, Traboco, Lisa S., Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garc ıa-De La Torre, Jesu´, s Loarce-Martos, Sergio Prieto-Gonza´ lez, Albert, Gil-Vila, Raquel Aranega Gonzalez, Masataka, Kuwana, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Johannes, Knitza, Stylianos, Tomaras, Margarita Aleksandrovna Gromova, Aharonov, Or, Gheita, Tamer A., Ihsane, Hmamouchi, Leonardo Santos Hoff, Margherita, Giannini, Franc¸ois, Maurier, Julien, Campagne, Alain, Meyer, Melinda, Nagy-Vincze, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Oce´ane, Landon-Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, Jose´ Anto´ nio Pereira Silva, Jo~ao Eurico Fonseca, Olena, Zimba.
Rok vydání: 2022
Předmět:
Zdroj: Rheumatology.
ISSN: 1462-0332
1462-0324
Popis: Objectives The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed to assess short-term COVID-19 vaccination-related adverse events (AEs) in RA patients. Methods An online self-reported questionnaire (March–December 2021) was used to capture data related to COVID-19 vaccination-related AEs in RA, other autoimmune rheumatic diseases (AIRDs) (excluding RA and inflammatory myositis), non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs). Descriptive and multivariable regression analyses were performed. Results Of the 9462 complete respondents, 14.2% (n = 1347) had been diagnosed with RA; they had a mean (s.d.) age of 50.7 (13.7) years, 74.2% were women and 49.3% were Caucasian. In total, 76.9% and 4.2% of patients with RA reported minor and major AEs, respectively. Patients with active and inactive RA had similar AE and hospitalization frequencies. Overall, AEs were reported more frequently by BNT162b2 and mRNA-1273 recipients and less frequently by BBV152 recipients compared with the rest. Major AE and hospitalization frequencies were similar across recipients of different vaccines. Patients receiving methotrexate and hydroxychloroquine reported fewer minor AEs than those patients not on them. Compared with HCs and patients with other AIRDs, patients with RA reported similar total AEs, overall minor AEs, and hospitalizations. Compared with nrAIDs, patients with RA reported lower frequencies of overall AEs, minor AEs (both odds ratio [OR] = 0.7; 95% CI: 0.5, 0.9), and injection site pain (OR = 0.6; 95% CI: 0.5, 0.8) with similar major AE and hospitalization frequencies. Conclusion Despite the differences in AE frequency across different COVID-19 vaccines, all were well tolerated in patients with RA and were comparable to HCs, providing reassurance as to the safety of COVID-19 vaccination.
Databáze: OpenAIRE
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