A comparison of arterial spin labeling and dynamic susceptibility perfusion imaging for resection control in glioblastoma surgery
| Autor: | Olav Jansen, Michael Synowitz, Thomas Lindner, Stephan Ulmer, Michael Helle, Julia Juhasz, Hajrullah Ahmeti |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Intraclass correlation Perfusion scanning in-vivo perfusion 030218 nuclear medicine & medical imaging magnetic resonance 03 medical and health sciences 0302 clinical medicine medicine Neuroradiology medicine.diagnostic_test business.industry glioblastoma imaging Magnetic resonance imaging medicine.disease Surgery Oncology Arterial spin labeling Neurosurgery business Perfusion 030217 neurology & neurosurgery Research Paper Glioblastoma |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.24970 |
| Popis: | // Thomas Lindner 1, * , Hajrullah Ahmeti 2, * , Julia Juhasz 1 , Michael Helle 3 , Olav Jansen 1 , Michael Synowitz 2 and Stephan Ulmer 1 1 Clinic for Radiology and Neuroradiology, UKSH Kiel, Kiel, Germany 2 Clinic for Neurosurgery, UKSH Kiel, Kiel, Germany 3 Philips Research Laboratories, Hamburg, Germany * These authors contributed equally to this work Correspondence to: Thomas Lindner, email: Thomas.Lindner@uksh.de Keywords: magnetic resonance; imaging; perfusion; glioblastoma; in-vivo Received: November 19, 2017 Accepted: March 18, 2018 Published: April 06, 2018 ABSTRACT Resection control using magnetic resonance imaging during neurosurgical interventions increases confidence regarding the extent of tumor removal already during the procedure. In addition to morphological imaging, functional information such as perfusion might become an important marker of the presence and extent of residual tumor mass. The aim of this study was to implement arterial spin labeling (ASL) perfusion imaging as a noninvasive alternative to dynamic susceptibility contrast (DSC) perfusion imaging in patients suffering from intra-axial tumors for resection control already during surgery. The study included 15 patients suffering from glioblastoma multiforme in whom perfusion imaging using DSC and ASL was performed before, during, and after surgery. The data obtained from intraoperative scanning were analyzed by two readers blinded to any clinical information, and the presence of residual tumor mass was evaluated using a ranking scale. Similarity of results was analyzed using the intraclass correlation coefficient and Pearson’s correlation coefficient. The results show that intraoperative ASL is as reliable as DSC when performing intraoperative perfusion imaging. According to the results of this study, intraoperative imaging using ASL represents an attractive alternative to contrast agent-based perfusion imaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|