The relationship between serum lactate dehydrogenase level and mortality in critically ill patients
| Autor: | Gang Wang, Jingjing Zhang, Xuting Jin, Jiajia Ren, Jiamei Li, Ruohan Li, Ya Gao, Dan Su |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Critical Illness Clinical Biochemistry Logistic regression Risk Assessment law.invention Sepsis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Lactate dehydrogenase Internal medicine Drug Discovery medicine Humans Hospital Mortality 030212 general & internal medicine Lactate Dehydrogenases Aged Retrospective Studies Critically ill business.industry Biochemistry (medical) Middle Aged Prognosis medicine.disease Intensive care unit Survival Rate Intensive Care Units chemistry Quartile Health evaluation 030220 oncology & carcinogenesis Female business Biomarkers Follow-Up Studies Serum lactate dehydrogenase level |
| Zdroj: | Biomarkers in Medicine. 15:551-559 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2020-0671 |
| Popis: | Background: To assess the association between serum lactate dehydrogenase (LDH) levels and mortality in intensive care unit patients. Materials & methods: A total of 1981 patients in the eICU Collaborative Research Database were divided into four groups according to quartiles of LDH levels. Logistic regressions were performed. Results: Elevated LDH levels were significantly associated with higher mortality (intensive care unit mortality: Q2 vs Q1: 1.046 [0.622–1.758]; Q3 vs Q1: 1.667 [1.029–2.699]; and Q4 vs Q1: 1.760 [1.092–2.839]). Similar results persisted in patients with different acute physiology and chronic health evaluation IV scores, and with or without sepsis. Conclusion: The serum LDH level may aid in the early identification of mortality risk in critically ill patients. |
| Databáze: | OpenAIRE |
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