Epstein-Barr virus infection in HIV-positive patients
| Autor: | Lukas Matter, Amalio Telenti, R. Malinverni, F Marchesi, Daniel Germann, D. E. Uehlinger |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Microbiology (medical) Herpesvirus 4 Human Opportunistic infection Molecular Sequence Data Cell Count HIV Infections medicine.disease_cause Polymerase Chain Reaction Herpesviridae Virus Cohort Studies hemic and lymphatic diseases medicine Humans Gammaherpesvirinae Antigens Viral Epstein–Barr virus infection Base Sequence biology Herpesviridae Infections General Medicine Middle Aged biology.organism_classification medicine.disease Epstein–Barr virus Virology DNA-Binding Proteins Tumor Virus Infections Infectious Diseases Epstein-Barr Virus Nuclear Antigens Immunology Female Viral disease Viral load |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 12:601-609 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/bf01973638 |
| Popis: | The relationship between Epstein-Barr virus (EBV) viral load in peripheral blood and HIV infection was determined in 103 HIV-infected patients. Epstein-Barr virus was detected by polymerase chain reaction in 75% of the patients, 21% of whom had the more uncommon EBV subtype 2. The highest levels of EBV were found in patients with 100-400 CD4+ cells/mm3 and not in those with more profound immunosuppression. An association was identified between EBV load and HIV proviral levels (p0.001), an IgM response to EBV early antigens (por = 0.01) and p24 antigenemia (p0.01 in patients with100 CD4+ cells), but not with other clinical or laboratory parameters. Combinations of different EBV and HIV parameters identified a subgroup of patients with a 2.2- to 4.8-fold risk ofor = 35% decline in CD4+ counts over six months. The association between EBV and HIV markers may reflect a significant pathogenic interaction between the two viruses. |
| Databáze: | OpenAIRE |
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