The Chinese herbal formulation biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trial
| Autor: | Diana J. Bass, Guorang Hu, Val Gebski, Mark Jones, DA Grayson, Ronald S. Walls, Ramon Bullock |
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| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Allergy Randomization Rhinitis Allergic Perennial Adolescent Immunology Administration Oral Pilot Projects Placebo law.invention Quality of life Randomized controlled trial Double-Blind Method law Statistical significance Internal medicine Immunopathology Surveys and Questionnaires medicine Immunology and Allergy Humans Aged Dose-Response Relationship Drug business.industry Immunoglobulin E Middle Aged medicine.disease Surgery Clinical trial Quality of Life Female business Drugs Chinese Herbal Follow-Up Studies |
| Zdroj: | Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 88(5) |
| ISSN: | 1081-1206 |
| Popis: | Background Herbal therapies have been widely used in allergic rhinitis (AR), but none have been shown to be effective in controlled scientific clinical trials. Objective The aim of this study was to test the effects of the Chinese herbal formulation Biminne in patients with moderate to severe perennial AR. Methods In a randomized, double-blind, placebo-controlled clinical trial, 58 patients were randomized to receive either Biminne capsules (n = 26) or placebo (n = 32) in doses of five capsules twice a day for 12 weeks. Main outcomes were measured by changes in symptom diaries, quality of life scores, patients' evaluations of improvement on visual analog scores, and physicians' overall evaluation. Total serum immunoglobulin E was measured in all patients without knowledge of which group they were in. After 1 year we performed a randomized, double-blind, dose-response study in 22 patients who had previously received placebo. Results The trial outcomes evaluated by four instruments showed a statistically significant improvement in some of the symptoms of AR, whereas others exhibited a positive trend that did not reach statistical significance. Followup 1 year after completion of the trial suggested that benefit of the treatment persisted. A pilot dose-response study showed both half and full strengths were effective. Total serum immunoglobulin E was reduced after the herbal treatment. Conclusions Our results suggest the Biminne formulation is effective in treatment of perennial AR. Its mode of action is unknown. |
| Databáze: | OpenAIRE |
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