Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
| Autor: | Anna Justyna Milewska, Łukasz Kurek, Maciej Żukowski, Natalia Data-Jabłońska, Aleksandra Lipka, Krzysztof Jabłoński, Karolina Żukowska, Marcin Jóźwik |
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| Rok vydání: | 2020 |
| Předmět: |
SERM therapy
elastography Pathology medicine.medical_specialty Population lcsh:Medicine Endometrium Article 03 medical and health sciences 0302 clinical medicine Breast cancer Uterine cancer medicine endometrium education education.field_of_study 030219 obstetrics & reproductive medicine tamoxifen medicine.diagnostic_test business.industry Endometrial cancer lcsh:R the softest endometrium layer ultrasonography General Medicine medicine.disease medicine.anatomical_structure Selective estrogen receptor modulator 030220 oncology & carcinogenesis endometrial cancer Elastography endometrial cancer screening business Tamoxifen medicine.drug |
| Zdroj: | Journal of Clinical Medicine Volume 9 Issue 12 Journal of Clinical Medicine, Vol 9, Iss 3870, p 3870 (2020) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm9123870 |
| Popis: | Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium&ndash endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography (p < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening. |
| Databáze: | OpenAIRE |
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