Treatment of viral hepatitis C genotypes 1 and 2 by sofosbuvir and ledipasvir with or without ribavirin combination: A possible alternative to pangenotypic treatment in a low-income country?
| Autor: | Andry Lalaina Rinà Rakotozafindrabe, Soloniaina Hélio Razafimahefa, Nitah Harivony Randriamifidy, Anjaramalala Sitraka Rasolonjatovo, Rado Manitrala Ramanampamonjy, T.H. Rabenjanahary, Chantelli Iamblaudiot Razafindrazoto |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cirrhosis Sofosbuvir Hepacivirus Infectious and parasitic diseases RC109-216 medicine.disease_cause Gastroenterology chemistry.chemical_compound 0302 clinical medicine Genotype Medicine Drug Interactions Viral hepatitis C 030212 general & internal medicine General Medicine Middle Aged Hepatitis C Treatment Outcome Infectious Diseases Ledipasvir Viral hepatitis medicine.drug Adult Microbiology (medical) Low income medicine.medical_specialty Hepatitis C virus 030106 microbiology Antiviral Agents Young Adult 03 medical and health sciences Internal medicine Ribavirin Madagascar Humans Developing Countries Aged Retrospective Studies Fluorenes business.industry medicine.disease chemistry Benzimidazoles business |
| Zdroj: | International Journal of Infectious Diseases, Vol 107, Iss, Pp 166-169 (2021) |
| ISSN: | 1201-9712 |
| Popis: | Objectives The aim of this study was to evaluate the efficacy and safety of sofosbuvir/ledipasvir ± ribavirin in Malagasy patients with hepatitis C virus genotypes 1 and 2, in real conditions. Patients and methods This was a retrospective monocentric clinical study, carried out over a period of 3 years from March 1, 2017 to February 28, 2020, in a hospital hepato-gastroenterology department. Results In total, 26 patients (M/F: 11/15) with hepatitis C virus genotype 1 (n = 13) or genotype 2 (n = 13), were treated with sofosbuvir/ledipasvir without (n = 21) or with (n = 5) ribavirin for 12 weeks. The mean age was 61.38 ± 7.09 years. Seventeen patients (65.4%) had cirrhosis. The overall sustained virological response was 96.2% (95% CI = 80.4–99.9%). There was no significant difference between the sustained virological responses of genotypes 1 and 2 (92.3% vs 100%; p = 0.31) or those of cirrhotic or non-cirrhotic patients (94.1% vs 100%; p = 0.46). A relapse was observed in one patient (5.9%) — cirrhotic and genotype 1b — under sofosbuvir/ledipasvir with ribavirin. Seven patients (26.9%) experienced mild adverse reactions, including asthenia (57.1%) and insomnia (42.9%). Conclusion Treatment with sofosbuvir/ledipasvir ± ribavirin for infection with hepatitis C virus genotype 1 has been shown to be safe and effective, even in the presence of cirrhosis. The sofosbuvir/ledipasvir combination is a good option for genotype 2 non-cirrhotic patients. |
| Databáze: | OpenAIRE |
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