Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
| Autor: | Abdulkarim Abdulrahman, Abdulla Ismaeel AlAwadhi, Manaf AlQahtani, Nitya Kumar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty Epidemiology medicine.medical_treatment media_common.quotation_subject Critical Illness Science Psychological intervention Comorbidity Article Internal medicine Respiratory signs and symptoms medicine Intubation Humans media_common Multidisciplinary biology business.industry SARS-CoV-2 Age Factors COVID-19 Odds ratio Middle Aged medicine.disease Confidence interval Glucosephosphate Dehydrogenase Deficiency Risk factors Outcomes research Viral infection Acute Disease biology.protein Breathing Glucose-6-Phosphatase Medicine Female business Glucose 6-phosphatase |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death—all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p = 0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds ratio 0.40, 95% confidence intervals 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association. |
| Databáze: | OpenAIRE |
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