The assessment of beta amyloid, tau protein and cystatin C in the cerebrospinal fluid: laboratory markers of neurodegenerative diseases
| Autor: | A. Suchy, Radko Obereigneru, J. Podivinsky, Jitka Vavrousková, Petr Hluštík, Petr Kanovsky, David Stejskal, J. Vesely, Jan Mares, Jana Zapletalová, Karel Urbánek, V. Pidrman, H. Vranova, Roman Herzig, Stanislav Burval |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Neurology Amyloid Tau protein tau Proteins Dermatology Young Adult Cerebrospinal fluid Alzheimer Disease Predictive Value of Tests Internal medicine mental disorders Post-hoc analysis medicine Humans Cystatin C Beta (finance) Aged Aged 80 and over Amyloid beta-Peptides biology General Medicine Middle Aged Peptide Fragments Up-Regulation Psychiatry and Mental health Endocrinology Nerve Degeneration biology.protein Female Neurology (clinical) Analysis of variance Psychology Biomarkers |
| Zdroj: | ResearcherID Web of Science |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | To assess the role of tau protein, beta-amyloid(1-42) and cystatin C in the diagnostics of Alzheimer dementia (AD) and other neurodegenerative diseases (ND) by comparing to the control groups (CG). The levels of tau protein, beta-amyloid(1-42) and cystatin C were assessed in the set of 69 patients (AD + ND, 33 males, 36 females, aged 22-90, mean 60.5 + 16.1 years), and in a control group of 69 subjects without the affection of the central nervous system (CGAD + CGND, 33 males, 36 females, aged 20-91, mean 60.5 + 16.0 years). Statistically significant increased tau protein levels (P = 0.0001) and index tau/beta-amyloid(1-42) levels (P = 0.0002) were shown in the group of AD patients, compared to the group of ND patients. One-way ANOVA analysis with Bonferonni post hoc test did not show any significant differences of the cystatin C values between any of the compared groups. ROC analysis showed at least one tie between the positive actual state group (AD) and the negative actual state group (ND) by CSF cystatin C and at least one tie between the positive actual state group and the negative actual state group by CSF tau protein. Our study confirmed previously reported results only in part. While tau protein seems to be quite a reliable marker of AD, the role of beta-amyloid(1-42) and cystatin C in AD diagnosis remains at least questionable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|