Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
| Autor: | E. Ramos-Morales, Laura Lyons, Jamie Tibble-Howlings, Charles J. Newbold, Radek Braganca, Magnus O. Ogbu, Patrick J. Murphy |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Rumen Chemical structure lcsh:Medicine Butyrate In Vitro Techniques Feed conversion ratio Article 03 medical and health sciences 0302 clinical medicine Parasitic Sensitivity Tests Enteric fermentation Animals Food science lcsh:Science Protozoan Infections Animal Multidisciplinary Chemistry Alkaloid lcsh:R food and beverages Biological activity Plants Animal Feed Diet Phenanthridines 030104 developmental biology 13. Climate action Fermentation Amaryllidaceae Alkaloids Animal Nutritional Physiological Phenomena Cattle lcsh:Q 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds and their interactions. Understanding the degree to which structural features in a compound may affect the biological activity of an extract is essential. We hypothesised that relative small variations in the structure of a compound can have a significant influence on the ability of the derivatives to alter fermentation in the rumen. Nine compounds were synthetized from the natural alkaloid haemanthamine and tested in vitro for their effects on rumen protozoa and fermentation parameters. Our results showed that simple esterifications of haemanthamine or its derivative dihydrohaemanthamine with acetate, butyrate, pivalate or hexanoate led to compounds that differed in their effects on rumen fermentation. |
| Databáze: | OpenAIRE |
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