Circuit directionality for motivation: lateral accumbens-pallidum, but not pallidum-accumbens, connections regulate motivational attraction to reward cues
| Autor: | Elizabeth B. Smedley, Alyssa DiLeo, Kyle S. Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Basal Forebrain Cognitive Neuroscience Experimental and Cognitive Psychology Nucleus accumbens 050105 experimental psychology Nucleus Accumbens Article Ventral pallidum Behavioral Neuroscience 03 medical and health sciences 0302 clinical medicine Reward Neural Pathways Animals Directionality 0501 psychology and cognitive sciences Rats Long-Evans 030304 developmental biology Neurons Motivation 0303 health sciences Behavior Animal 05 social sciences Attraction Rats Incentive salience Cues Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiol Learn Mem |
| DOI: | 10.1101/474387 |
| Popis: | Sign-tracking behavior, in which animals interact with a cue that predicts reward, provides an example of how incentive salience can be attributed to cues and elicit motivation. The nucleus accumbens (NAc) and ventral pallidum (VP) are two regions involved in cue-driven motivation. The VP, and subregions of the NAc including the medial shell and core, are critical for sign-tracking, and connections between the medial shell and VP are known to participate in sign-tracking and other motivated behaviors. The NAc lateral shell (NAcLSh) is a distinct and understudied subdivision of the NAc, and its contribution to the process by which reward cues acquire value remains unclear. The NAcLSh has been implicated in reward-directed behavior, and has reciprocal connections with the VP, suggesting that NAcLSh and VP interactions could be important mechanisms for incentive salience. Here, we use DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) and an intersectional viral delivery strategy to produce a biased inhibition of NAcLSh neurons projecting to the VP, and vice versa. We find that disruption of connections from NAcLSh to VP reduces sign-tracking behavior while not affecting consumption of food rewards. In contrast, VP to NAcLSh disruption affected neither sign-tracking nor reward consumption, but did produce a greater shift in animals’ behavior more towards the reward source when it was available. These findings indicate that the NAcLSh→VP pathway plays an important role in guiding animals towards reward cues, while VP→NAcLSh back-projections may not and may instead bias motivated behavior towards rewards. |
| Databáze: | OpenAIRE |
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