Early and late effects of accelerated charged particles on normal tissues
| Autor: | Kay H. Woodruff, Bernard S. Lewinsky, Patricia Smith, J. Howard, John Lyman, J.T. Leith |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Cancer Research
Time Factors chemistry.chemical_element Neon Bragg peak Helium Ion Mice Cricetinae Ionization Animals Medicine Radiology Nuclear Medicine and imaging Irradiation Skin Ions Radiation business.industry Radiochemistry Dose-Response Relationship Radiation Charged particle Rats Energy Transfer Spinal Cord Oncology chemistry Helium ions business Relative Biological Effectiveness |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 3:103-108 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(77)90235-8 |
| Popis: | The response of skin and spinal cord to accelerated charged particle irradiation has been examined. For skin, irradiation with helium or neon ions in the plateau region of ionization yields RBE values (compared to 230 kV X-rays) of about 1.0 and 1.5 respectively. Irradiation with helium or neon ions in a therapeutically modified (“spread-out”) Bragg peak region of ionization yields RBE values of about 1.3 and 2.2–2.5 respectively. After exposure to divided doses of either helium or neon ions in the spread-out Bragg peak region of ionization, the amount of dose recovered appeared to be decreased by about 30% (as compared to the amount of dose recovered after exposure to divided doses of X-rays given over an interval of 24 hr) for the helium ion irradiations, and appeared to be decreased by about 75% for the neon ion irradiations. For effects on spinal cord, the degree of myelopathy appeared to be similar after irradiation with helium ions in either the plateau or spread-out Bragg peak regions of ionization; while after exposure to neon ions in the plateau region of ionization, the RBE appeared to be about 1.3. |
| Databáze: | OpenAIRE |
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