Serum Uric Acid and Outcome after Acute Ischemic Stroke: PREMIER Study
| Autor: | Alma Ramos-Moreno, José Luis Ruiz-Sandoval, Luis Manuel Murillo-Bonilla, Diego R. Orozco-Valera, Ana Ochoa-Guzmán, Carlos Cantú-Brito, Antonio Arauz, Carolina León-Jiménez, Jorge Villarreal-Careaga, Fernando Barinagarrementeria, Erwin Chiquete |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Time Factors Antioxidant medicine.medical_treatment Gastroenterology Brain Ischemia Disability Evaluation chemistry.chemical_compound Risk Factors Odds Ratio Prospective Studies Registries Prospective cohort study Acute ischemic stroke Stroke Aged 80 and over Stroke Rehabilitation Middle Aged Prognosis Neurology Female Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty Hyperuricemia Risk Assessment Young Adult Predictive Value of Tests Internal medicine medicine Humans Mexico Aged Creatinine Chi-Square Distribution business.industry Serum uric acid Recovery of Function Odds ratio medicine.disease Uric Acid Surgery Logistic Models chemistry Multivariate Analysis Uric acid Neurology (clinical) business Biomarkers |
| Zdroj: | Cerebrovascular Diseases. 35:168-174 |
| ISSN: | 1421-9786 1015-9770 |
| Popis: | Background: Current evidence shows that uric acid is a potent antioxidant whose serum concentration increases rapidly after acute ischemic stroke (AIS). Nevertheless, the re-lationship between serum uric acid (SUA) levels and AIS outcome remains debatable. We aimed to describe the prognostic significance of SUA in AIS. Methods: We studied 463 patients (52% men, mean age 68 years, 13% with glomerular filtration rate Results: Mean SUA concentration at hospital arrival was 6.1 ± 3.7 mg/dl (362.8 ± 220.0 μmol/l). Compared with cases with higher SUA levels at hospital admission, patients with ≤4.5 mg/dl (≤267.7 μmol/l; the lowest tertile of the sample) had more cases of a very good 30-day outcome (30.5 vs. 18.9%, respectively; p = 0.004). SUA was not associated with mortality or functional dependence (mRS >2) at 30 days, or with any outcome measure at 3, 6 or 12 months poststroke. After adjustment for age, gender, stroke type and severity (NIHSS Conclusions: A low SUA concentration is modestly associated with a very good short-term outcome. Our findings support the hypothesis that SUA is more a marker of the magnitude of the cerebral infarction than an independent predictor of stroke outcome. |
| Databáze: | OpenAIRE |
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