The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder
| Autor: | Josephine DeGuzman, Kristen Lyall, Gayle C. Windham, Jianwen She, Ying Li, Kimberly Berger, M Kharrazi, Paramjit Behniwal, Michelle Pearl |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Autism Spectrum Disorder Tobacco smoke 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy mental disorders medicine Humans 0501 psychology and cognitive sciences Child Cotinine Genetics (clinical) Smoke Obstetrics business.industry General Neuroscience Smoking 05 social sciences Odds ratio medicine.disease chemistry Maternal Exposure Autism spectrum disorder In utero Autism Female Tobacco Smoke Pollution Neurology (clinical) business 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Zdroj: | Autism Research. 14:2017-2026 |
| ISSN: | 1939-3806 1939-3792 |
| Popis: | Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (≥3.08 ng/ml vs. |
| Databáze: | OpenAIRE |
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