Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella
| Autor: | Hongfang Liu, Liyan Xi, Xiaowen Huang, Yinghui Liu, Chester R. Cooper |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Fonsecaea
animal structures Mutant Virulence Microbiology Melanin Immune system Ascomycota medicine Animals Pathogen Melanins Chromoblastomycosis biology Histocytochemistry fungi General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Galleria mellonella Lepidoptera Disease Models Animal Infectious Diseases Mycoses Mutation |
| Zdroj: | Medical mycology. 57(8) |
| ISSN: | 1460-2709 |
| Popis: | Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. monophora in Galleria mellonella model using melanin and albino strain. Interestingly, the albino mutant strain displayed higher pathogenicity compared to the melanin stain and restoration of melanin of albino mutant could reverse the pathogenicity. Histopathology showed that inflammatory nodules were bigger than that infected with albino cells, which suggested that melanized cells could trigger a robust cellular immune response of G. mellonella than albino cells. The activated immune response in G. mellonella induced by melanized cells might explain the decreased virulence of melanized cells in larvae model. While further study was needed to gain full insights into the molecular immunological mechanism in G. mellonella activated by melanin. |
| Databáze: | OpenAIRE |
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