Cutis tricolor: a literature review and report of five new cases

Autor: Massimiliano Morano, Stefano Palmucci, Martino Ruggieri, Concetta Pirrone, Emanule David, Vincenzo Salpietro, Pietro Milone, Serena Strano, Carmelo Schepis, Agata Polizzi, Pietro Valerio Foti, Mario Roggini, Giuseppe Belfiore
Rok vydání: 2016
Předmět:
Zdroj: Quantitative imaging in medicine and surgery
6 (2016): 525–534. doi:10.21037/qims.2016.10.14
info:cnr-pdr/source/autori:Ruggieri M.; Polizzi A.; Schepis C.; Morano M.; Strano S.; Belfiore G.; Palmucci S.; Foti P.V.; Pirrone C.; Roggini M.; David E.; Salpietro V.; Milone P./titolo:Cutis tricolor: A literature review and report of five new cases/doi:10.21037%2Fqims.2016.10.14/rivista:Quantitative imaging in medicine and surgery (Print)/anno:2016/pagina_da:525/pagina_a:534/intervallo_pagine:525–534/volume:6
ISSN: 2223-4306
2223-4292
DOI: 10.21037/qims.2016.10.14
Popis: Background: Cutis tricolor is a skin abnormality consisting in a combination of congenital hyper-and hypopigmented skin lesions (in the form of paired macules, patches or streaks) in close proximity to each other in a background of normal skin. It is currently regarded as a twin-spotting (mosaic) phenomenon and today is clear that not all cases of cutis tricolor represent one single entity. This phenomenon has been reported so far either: (I) as an purely cutaneous trait; (II) as a part of a complex malformation phenotype (Ruggieri-Happle syndrome, RHS) including distinct facial features, eye (cataract), skeletal (skull and vertebral defects, and long bones dysplasia), nervous system (corpus callosum, cerebellar and white matter anomalies, cavum vergae and holoprosencephaly) and systemic abnormalities; (III) as a distinct type with multiple, disseminated smaller skin macules (cutis tricolor parvimaculata); and (IV) in association with other skin disturbances [e.g., cutis marmorata telangectasica congenita (phacomatosis achromico-melano-marmorata)] or in the context of other skin (e.g., ataxia-Telangiectasia and phacomatosis pigmentovascularis, PPV) or complex malformation phenotypes (e.g., microcephaly and dwarfism). Methods: (I) Review of the existing literature; and (II) information on our personal experience (clinical, laboratory and imaging data) on new cases with cutis tricolor seen and followed-up at our institutions during years 2010-2016.Results: The existing literature revealed 19 previous studies (35 cases) with pure cutaneous or syndromic cutis tricolor phenomena. Our personal experience included 5 unpublished patients (3 boys; 2 girls; currently aged 2 to 14 years) seen and followed-up at our Institutions in Italy who had: (I) skin manifestations of the cutis tricolor type (N=5); (II) skeletal abnormalities including small skull (n=2), obtuse angle of mandible (n=3), mild to moderate scoliosis (n=3), vertebral defects (n=3), and long bones bowing (n=3); mild psychomotor delay (n=3); epilepsy (n=2); anomalies of the corpus callosum (n=3); and cavum vergae (n =2). Conclusions: This study further confirms and expands the overall phenotype of cutis tricolor. By literature review and personal experience we conclude that the skin abnormalities of the cutis tricolor type are stable over time; the skeletal defects are mild to moderate and do not progress or cause relevant orthopaedic complications; the neurological/behavioural phenotype does not progress and the paroxysmal events (when present) tend to decrease over time; there is a typical facial phenotype in some patients (long, elongated face, thick and brushy eyebrows, hypertelorism, deep nasal bridge with large bulbous nose and anteverted nostrils), which characterizes a somewhat distinct syndromic phenotype; some patients may develop early onset cataracts. The allelic dydymotic hypothesis of post-zygotic mutations likely involving the same gene loci could well explain the overall skin, bone, lens and nervous system phenomena of migration of different streaks of clones in the different tissues.
Databáze: OpenAIRE
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