Spasmolytic stilbenoids from Maxillaria densa
| Autor: | Juan Javier López-Guerrero, S. Estrada, Rafael Villalobos-Molina, Rachel Mata |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Ileum Gymnopusin Pharmacognosy Pharmacology chemistry.chemical_compound Stilbenes Drug Discovery medicine Animals Erianthridin Rats Wistar Orchidaceae Mode of action Papaverine Dose-Response Relationship Drug Plant Extracts Chemistry Barium chloride Parasympatholytics General Medicine Rats medicine.anatomical_structure Biochemistry Histamine Muscle Contraction Phytotherapy medicine.drug |
| Zdroj: | Fitoterapia. 75:690-695 |
| ISSN: | 0367-326X |
| Popis: | 2,5-Dihydroxy-3,4-dimethoxyphenanthrene (1), fimbriol-A (2), nudol (3), gymnopusin (4) and erianthridin (5) isolated from Maxillaria densa provoked a concentration-dependent inhibition of the spontaneous contractions of the rat ileum with potencies comparable to papaverine. In order to establish the mode of action of stilbenoids 1–5, their effect on the contractions induced by different spasmogens (histamine, barium chloride and l -NAME) was investigated. In general, the results suggested that the relaxant activity of the products does not involve a direct nitrergic or antihistaminergic mode of action or an interference with calcium influx into the smooth muscle cells. |
| Databáze: | OpenAIRE |
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