Acute Heart Rate-Dependent Hemodynamic Function of the Heart in the Post-Myocardial Infarction Rat Model: Change Over Time
| Autor: | Przemysław Leszek, Michał Mączewski, Urszula Mackiewicz, Aleksandra Paterek, Joanna Kołodziejczyk, Marta Kępska |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Cardiac output Time Factors Heart Ventricles Myocardial Infarction Hemodynamics 030204 cardiovascular system & hematology Rats Inbred WKY 03 medical and health sciences Random Allocation 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Animals Myocardial infarction Cardiac Output Heart Failure Ejection fraction Ventricular Remodeling business.industry medicine.disease Rats Preload Disease Models Animal 030104 developmental biology Echocardiography Heart failure Cardiology Disease Progression Myocardial infarction complications Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Canadian journal of cardiology. 34(10) |
| ISSN: | 1916-7075 |
| Popis: | Background Optimal heart rate (HR) for acute hemodynamic efficiency in heart failure (HF) is unknown. Methods Wistar-Kyoto rats were followed-up for 3 and 7 days, 1 or 2 months after myocardial infarction (MI) or sham operation (ShO) and left ventricle (LV) pressure-volume (PV) loops were obtained at various HRs: baseline 400 beats per minute (bpm), reduced by ivabradine to 320 bpm, increased by atrial pacing to 480 bpm, under normal conditions and after preload increase (PI). Results In the ShO group, PI augmented cardiac output (CO) by 55%, 67%, 84% at reduced, baseline, and increased HR, respectively. In post-MI rats, PI augmented CO 3 and 7 days, but not 1 and 2 months after MI. At increased HR, in response to PI, CO increased 3 and 7 days, tended to fall 1 and 2 months after MI; this hemodynamic response was salvaged by HR reduction. Further beneficial effects of HR reduction included reduction of LV end-diastolic pressure, increase of ejection fraction, contractility and relaxation velocity 1 and 2 months after MI. Conclusions In a rat HF model, optimal HR with regard to acute hemodynamic performance is shifted. Whereas in ShO rats increased HR facilitates CO increase induced by PI, in HF rats, such increase reduces CO, and HR reduction has beneficial effects. Thus, besides reducing progression of HF, HR-reducing interventions also offer immediate hemodynamic benefits. |
| Databáze: | OpenAIRE |
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