RNA-directed DNA repair and antibody somatic hypermutation
| Autor: | Edward J. Steele, Andrew Franklin |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Mutation
DNA Repair biology DNA repair Somatic hypermutation RNA DNA DNA-Directed DNA Polymerase medicine.disease_cause Molecular biology Deoxyuridine Reverse transcriptase chemistry.chemical_compound chemistry RNA editing Cytidine Deaminase Genetics biology.protein medicine Humans Somatic Hypermutation Immunoglobulin Polymerase |
| Zdroj: | Trends in Genetics. 38:426-436 |
| ISSN: | 0168-9525 |
| DOI: | 10.1016/j.tig.2021.10.005 |
| Popis: | Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) pairs. Deamination of C to deoxyuridine (U) by activation-induced deaminase (AID) explains how mutation at C/G pairs is potentiated. Mutation at A/T pairs is triggered during the initial stages of repair of AID-generated U lesions and occurs through an as yet unknown mechanism in which polymerase η has a major role. Recent evidence confirms that human polymerase η can act as a reverse transcriptase. Here, we compare the popular suggestion of mutation at A/T pairs through nucleotide mispairing (owing to polymerase error) during short-patch repair synthesis with the alternative proposal of mutation at A/T pairs through RNA editing and RNA-directed DNA repair. |
| Databáze: | OpenAIRE |
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