A new type of variation among the polyoma viruses characterized by cytoplasmic accumulation of capsid antigen
| Autor: | J. Donald Hare |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Genetics
Microbial Cytoplasm viruses Fluorescent Antibody Technique Hamster Biology Tritium Viral Function Mice Multiplicity of infection Antigen Cricetinae Culture Techniques Virology medicine Animals Antigens Cell Nucleus Immune Sera Genetic Variation Fibroblasts biochemical phenomena metabolism and nutrition Group-specific antigen Embryo Mammalian Molecular biology medicine.anatomical_structure Capsid Depression Chemical DNA Viral Mutation Rabbits Floxuridine Polyomavirus Nucleus Thymidine |
| Zdroj: | Virology. 40:978-988 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/0042-6822(70)90144-3 |
| Popis: | By immunofluorescent techniques, capsid antigen of the 3049 strain of polyoma virus was found in the cytoplasm early in the infectious cycle followed by its gradual appearance in the nucleus. This is distinct from the capsid antigen of other polyoma strains, which reaches concentrations sufficient to be visualized only in the nucleus. This characteristic, termed CyC+, is stable and is unrelated to antigenic type or plaque size as well as multiplicity of infection. The synthesis of “T” antigen and infectious virions is normal. Capsid antigen formation is inhibited by DNA synthesis inhibition as in other polyoma strains. Of interest is the finding that capsid antigen appeared only in the nucleus of hamster embryo cells, perhaps providing a unique example of host control over a viral function. |
| Databáze: | OpenAIRE |
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