Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric Precursors
| Autor: | Todd Hoare, Niels M. B. Smeets, Trevor Gilbert |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Materials science Morphology (linguistics) Polymers and Plastics Organic Chemistry Mixing (process engineering) Hydrazone Context (language use) 02 engineering and technology Dynamic mechanical analysis 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry Self-healing hydrogels Polymer chemistry Materials Chemistry medicine Interpenetrating polymer network Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | ACS Macro Letters. 4:1104-1109 |
| ISSN: | 2161-1653 |
| DOI: | 10.1021/acsmacrolett.5b00362 |
| Popis: | The enhanced mechanics, unique chemistries, and potential for domain formation in interpenetrating network (IPN) hydrogels have attracted significant interest in the context of biomedical applications. However, conventional IPNs are not directly injectable in a biological context, limiting their potential utility in such applications. Herein, we report a fully injectable and thermoresponsive interpenetrating polymer network formed by simultaneous reactive mixing of hydrazone cross-linked poly(N-isopropylacrylamide) (PNIPAM), and thiosuccinimide cross-linked poly(N-vinylpyrrolidone) (PVP). The resulting IPN gels rapidly ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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